Sintaxe Catarina

Ao relacionar de modo quantitativo padrões de configuração espacial com os modos de apropriação social, essa teoria abriu possibilidades para diferentes análises da espacialidade de cidades e edificações. No Brasil, desde a década de 1980, diversos pesquisadores e profissionais têm-se utilizado da TSE para seus trabalhos e, atualmente, há grupos de pesquisa em diferentes centros universitários. Parte da produção desenvolvida no estado de Santa Catarina com base nessa abordagem é apresentada nesta coletânea, evidenciando que muitas das expectativas e tendências de desenvolvimento urbano surgidas dessas pesquisas ainda não foram devidamente equacionadas, o que reforça a sua pertinência na atualidade

Sintaxe Catarina

Ao relacionar de modo quantitativo padrões de configuração espacial com os modos de apropriação social, essa teoria abriu possibilidades para diferentes análises da espacialidade de cidades e edificações. No Brasil, desde a década de 1980, diversos pesquisadores e profissionais têm-se utilizado da TSE para seus trabalhos e, atualmente, há grupos de pesquisa em diferentes centros universitários. Parte da produção desenvolvida no estado de Santa Catarina com base nessa abordagem é apresentada nesta coletânea, evidenciando que muitas das expectativas e tendências de desenvolvimento urbano surgidas dessas pesquisas ainda não foram devidamente equacionadas, o que reforça a sua pertinência na atualidade

Spatial and Temporal Pattern of Rift Valley Fever Outbreaks in Tanzania; 1930 to 2007

Rift Valley fever (RVF)-like disease was first reported in Tanzania more than eight decades ago and the last large outbreak of the disease occurred in 2006–07. This study investigates the spatial and temporal pattern of RVF outbreaks in Tanzania over the past 80 years in order to guide prevention and control strategies. A retrospective study was carried out based on disease reporting data from Tanzania at district or village level. The data were sourced from the Ministries responsible for livestock and human health, Tanzania Meteorological Agency and research institutions involved in RVF surveillance and diagnosis. The spatial distribution of outbreaks was mapped using ArcGIS 10. The space-time permutation model was applied to identify clusters of cases, and a multivariable logistic regression model was used to identify risk factors associated with the occurrence of outbreaks in the district. RVF outbreaks were reported between December and June in 1930, 1947, 1957, 1960, 1963, 1968, 1977– 79, 1989, 1997–98 and 2006–07 in 39.2% of the districts in Tanzania. There was statistically significant spatio-temporal clustering of outbreaks. RVF occurrence was associated with the eastern Rift Valley ecosystem (OR = 6.14, CI: 1.96, 19.28), total amount of rainfall of .405.4 mm (OR = 12.36, CI: 3.06, 49.88), soil texture (clay [OR = 8.76, CI: 2.52, 30.50], and loam [OR = 8.79, CI: 2.04, 37.82]). RVF outbreaks were found to be distributed heterogeneously and transmission dynamics appeared to vary between areas. The sequence of outbreak waves, continuously cover more parts of the country. Whenever infection has been introduced into an area, it is likely to be involved in future outbreaks. The cases were more likely to be reported from the eastern Rift Valley than from the western Rift Valley ecosystem and from areas with clay and loam rather than sandy soil texture

One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke

BACKGROUND Previous studies conducted between 1997 and 2003 estimated that the risk of stroke or an acute coronary syndrome was 12 to 20% during the first 3 months after a transient ischemic attack (TIA) or minor stroke. The TIAregistry.org project was designed to describe the contemporary profile, etiologic factors, and outcomes in patients with a TIA or minor ischemic stroke who receive care in health systems that now offer urgent evaluation by stroke specialists. METHODS We recruited patients who had had a TIA or minor stroke within the previous 7 days. Sites were selected if they had systems dedicated to urgent evaluation of patients with TIA. We estimated the 1-year risk of stroke and of the composite outcome of stroke, an acute coronary syndrome, or death from cardiovascular causes. We also examined the association of the ABCD2 score for the risk of stroke (range, 0 [lowest risk] to 7 [highest risk]), findings on brain imaging, and cause of TIA or minor stroke with the risk of recurrent stroke over a period of 1 year. RESULTS From 2009 through 2011, we enrolled 4789 patients at 61 sites in 21 countries. A total of 78.4% of the patients were evaluated by stroke specialists within 24 hours after symptom onset. A total of 33.4% of the patients had an acute brain infarction, 23.2% had at least one extracranial or intracranial stenosis of 50% or more, and 10.4% had atrial fibrillation. The Kaplan–Meier estimate of the 1-year event rate of the composite cardiovascular outcome was 6.2% (95% confidence interval, 5.5 to 7.0). Kaplan–Meier estimates of the stroke rate at days 2, 7, 30, 90, and 365 were 1.5%, 2.1%, 2.8%, 3.7%, and 5.1%, respectively. In multivariable analyses, multiple infarctions on brain imaging, large-artery atherosclerosis, and an ABCD2 score of 6 or 7 were each associated with more than a doubling of the risk of stroke. CONCLUSIONS We observed a lower risk of cardiovascular events after TIA than previously reported. The ABCD2 score, findings on brain imaging, and status with respect to large-artery atherosclerosis helped stratify the risk of recurrent stroke within 1 year after a TIA or minor stroke. (Funded by Sanofi and Bristol-Myers Squibb.)Supported by an unrestricted grant from Sanofi and Bristol-Myers Squibb

Субстанціональне обмеження демократії в умовах глобалізації

Геращенко, Т. Г. Субстанціональне обмеження демократії в умовах глобалізації / Тетяна Григорівна Геращенко // Актуальні проблеми правової науки і державотворення в Україні в контексті правової інтеграції : матеріали ХІ Міжнародної науково-практичної конференції (18-19 травня 2018 року, м. Суми) / Сумська філія Харківського національного університету внутрішніх справ. – Суми: Видавничий дім «Ельдорадо», 2018. – С. 138-139.Основна проблема нашого часу не в глобалізації, а в тому, що сучасне політичне співтовариство не зможе вижити без демократичного розв’язання проблеми глобалізації. Однак у своєму нинішньому вигляді воно не в змозі прийняти подібного рішення. У цьому полягає субстанціональне обмеження демократії: нездатність окреслити свої власні кордони і межі власної легітимності.The main problem of our time is not globalization, but the fact that the modern political community will not be able to survive without a democratic solution to the problem of globalization. However, in its current form, it is unable to make such a decision. This is a substantial limitation of democracy: the inability to define one's own boundaries and limits of one's own legitimacy.Основная проблема нашего времени не в глобализации, а в том, что современное политическое сообщество не сможет выжить без демократического решения проблемы глобализации. Однако в своем нынешнем виде оно не в состоянии принять подобное решение. В этом состоит субстанциональное ограничение демократии: неспособность определить свои собственные границы и пределы собственной легитимности

Associations between attributes of live poultry trade and HPAI H5N1 outbreaks: a descriptive and network analysis study in northern Vietnam

Background: The structure of contact between individuals plays an important role in the incursion and spread of contagious diseases in both human and animal populations. In the case of avian influenza, the movement of live birds is a well known risk factor for the geographic dissemination of the virus among poultry flocks. Live bird markets (LBM's) contribute to the epidemiology of avian influenza due to their demographic characteristics and the presence of HPAI H5N1 virus lineages. The relationship between poultry producers and live poultry traders (LPT's) that operate in LBM's has not been adequately documented in HPAI H5N1-affected SE Asian countries. The aims of this study were to document and study the flow of live poultry in a poultry trade network in northern Vietnam, and explore its potential role in the risk for HPAI H5N1 during 2003 to 2006

The Gut Microbiome in Polycystic Ovary Syndrome and Its Association with Metabolic Traits

Context: Despite the gut microbiome being widely studied in metabolic diseases, its role in polycystic ovary syndrome (PCOS) has been scarcely investigated. Objective: Compare the gut microbiome in late fertile age women with and without PCOS and investigate whether changes in the gut microbiome correlate with PCOSrelated metabolic parameters. Design: Prospective, case-control study using the Northern Finland Birth Cohort 1966. Setting: General community. Participants: A total of 102 PCOS women and 201 age- and body mass index (BMI)matched non-PCOS control women. Clinical and biochemical characteristics of the participants were assessed at ages 31 and 46 and analyzed in the context of gut microbiome data at the age of 46. Intervention(s): None Main outcome measure(s): Bacterial diversity, relative abundance, and correlations with PCOS-related metabolic measures. Results: Bacterial diversity indices did not differ significantly between PCOS and controls (Shannon diversity P =.979, unweighted UniFrac P =.175). Four genera whose balance helps to differentiate between PCOS and non-PCOS were identified. In the whole cohort, the abundance of 2 genera from Clostridiales, Ruminococcaceae UCG-002, and Clostridiales Family XIII AD3011 group, were correlated with several PCOS-related markers. Prediabetic PCOS women had significantly lower alpha diversity (Shannon diversity P =.018) and markedly increased abundance of genus Dorea (false discovery rate = 0.03) compared with women with normal glucose tolerance. Conclusion: PCOS and non-PCOS women at late fertile age with similar BMI do not significantly differ in their gut microbial profiles. However, there are significant microbial changes in PCOS individuals depending on their metabolic health.Peer reviewe

Article structure peculiarities in the context of academic writing

Serhiienko, A. Article structure peculiarities in the context of academic writing / Anastasiia Serhiienko, Tatiana Serhiienko // Актуальні проблеми правової науки і державотворення в Україні в контексті правової інтеграції : матеріали ХІ Міжнародної науково-практичної конференції (18-19 травня 2018 року, м. Суми) / Сумська філія Харківського національного університету внутрішніх справ. – Суми: Видавничий дім «Ельдорадо», 2018. – С. 125-127.Багато авторів зтикаються з труднощами подання та схвалення наукової статті до публікації у авторитетних наукових виданнях. Основна проблема вбачається у некоректному структуруванні елементів наукової праці. Авторами наводяться основні компоненти наукової статті, їх загальнодопустимий об’єм та деякі зауваження щодо їх викладення.Many authors face difficulties in submitting and approving a scientific article for publication in authoritative scientific publications. The main problem is seen in the incorrect structuring of the elements of scientific work. The authors present the main components of a scientific article, their generally acceptable volume and some remarks on their presentation.Многие авторы сталкиваются с трудностями представления и одобрения научной статьи к публикации в авторитетных научных изданиях. Основная проблема усматривается в некорректном структурировании элементов научного труда. Авторами приводятся основные компоненты научной статьи, их общедопустимый объем и некоторые замечания по их изложению

Genome-wide promoter analysis of histone modifications in human monocyte-derived antigen presenting cells

<p>Abstract</p> <p>Background</p> <p>Monocyte-derived macrophages and dendritic cells (DCs) are important in inflammatory processes and are often used for immunotherapeutic approaches. Blood monocytes can be differentiated into macrophages and DCs, which is accompanied with transcriptional changes in many genes, including chemokines and cell surface markers.</p> <p>Results</p> <p>To study the chromatin modifications associated with this differentiation, we performed a genome wide analysis of histone H3 trimethylation on lysine 4 (H3K4me3) and 27 (H3K27me3) as well as acetylation of H3 lysines (AcH3) in promoter regions. We report that both H3K4me3 and AcH3 marks significantly correlate with transcriptionally active genes whereas H3K27me3 mark is associated with inactive gene promoters. During differentiation, the H3K4me3 levels decreased on monocyte-specific CD14, CCR2 and CX3CR1 but increased on DC-specific TM7SF4/DC-STAMP, TREM2 and CD209/DC-SIGN genes. Genes associated with phagocytosis and antigen presentation were marked by H3K4me3 modifications. We also report that H3K4me3 levels on clustered chemokine and surface marker genes often correlate with transcriptional activity.</p> <p>Conclusion</p> <p>Our results provide a basis for further functional correlations between gene expression and histone modifications in monocyte-derived macrophages and DCs.</p

Applications of Machine Learning in Human Microbiome Studies: A Review on Feature Selection, Biomarker Identification, Disease Prediction and Treatment

The number of microbiome-related studies has notably increased the availability of data on human microbiome composition and function. These studies provide the essential material to deeply explore host-microbiome associations and their relation to the development and progression of various complex diseases. Improved data-analytical tools are needed to exploit all information from these biological datasets, taking into account the peculiarities of microbiome data, i.e., compositional, heterogeneous and sparse nature of these datasets. The possibility of predicting host-phenotypes based on taxonomy-informed feature selection to establish an association between microbiome and predict disease states is beneficial for personalized medicine. In this regard, machine learning (ML) provides new insights into the development of models that can be used to predict outputs, such as classification and prediction in microbiology, infer host phenotypes to predict diseases and use microbial communities to stratify patients by their characterization of state-specific microbial signatures. Here we review the state-of-the-art ML methods and respective software applied in human microbiome studies, performed as part of the COST Action ML4Microbiome activities. This scoping review focuses on the application of ML in microbiome studies related to association and clinical use for diagnostics, prognostics, and therapeutics. Although the data presented here is more related to the bacterial community, many algorithms could be applied in general, regardless of the feature type. This literature and software review covering this broad topic is aligned with the scoping review methodology. The manual identification of data sources has been complemented with: (1) automated publication search through digital libraries of the three major publishers using natural language processing (NLP) Toolkit, and (2) an automated identification of relevant software repositories on GitHub and ranking of the related research papers relying on learning to rank approach.This study was supported by COST Action CA18131 “Statistical and machine learning techniques in human microbiome studies”. Estonian Research Council grant PRG548 (JT). Spanish State Research Agency Juan de la Cierva Grant IJC2019-042188-I (LM-Z). EO was founded and OA was supported by Estonian Research Council grant PUT 1371 and EMBO Installation grant 3573. AG was supported by Statutory Research project of the Department of Computer Networks and Systems